Sepsis

Humans have co-existed with commensals and pathogens for the duration of our evolution. Our immune responses have adapted to these interactions, and specifically also to changes in the relationship from commensal to pathogen. BloodCounts! Sepsis aims to leverage ultra granular full blood count (FBC) data, clinical and special investigation data from electronic health records (EHR) and advanced artificial intelligence (AI) tools to recognise the resultant signatures expressed in the host (immune) response and thereby enhance the prediction, detection, and individualised, patient centred management of sepsis.

• Sepsis is a leading cause of death globally. There are about 50 million cases per year and 11 million deaths annually, representing about 1 in 5 of all deaths.

• Low- and middle-income countries are disproportionately represented, and 40% of cases are in children under the age of 5.

• High-income countries are not spared, with 3.4 million cases and 680,000 deaths per year in Europe

• 15 out of every 1,000 hospitalised patients will develop sepsis as a complication of receiving health care.

• Sepsis results in large health care costs; $62 billion in the USA and $9 billion in Germany per year.